NMDA Receptor Antagonists and Autism

NMDA receptor antagonists are a class of anesthetics that work to antagonise (inhibit) the action of the N-methyl d-aspartate receptor (NMDAR).

NMDA receptor antagonists sometimes used to treat people on the autism spectrum include

• Amantadine
• Memantine

Related Glossaries

• NMDA Receptor Antagonists

Related Publications

• Aman M. G. et al. (2017) Safety and efficacy of memantine in children with autism: Randomized, placebo-controlled study and open-label extension. Journal of Child and Adolescent Psychopharmacology. 27(5), Read Abstract (New Window) Read Full (New Window)
  
  
• Chez M. G. et al. (2007) Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability. Journal of Child Neurology. 22(5), Read Abstract (New Window)
  
  
• Erickson C. A., Chambers J. (2006) Memantine for disruptive behavior in autistic disorder. Journal of Clinical Psychiatry. 67(6),
  
  
• Joshi G. et al. (2016) A prospective open-label trial of memantine hydrochloride for the treatment of social deficits in intellectually capable adults with autism spectrum disorder. Journal of Psychopharmacology. 36(3), Read Abstract (New Window)
  
  
• King B. H. et al. (2001) Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 40(6), Read Abstract (New Window)
  
  
• Nikvarz N. N. et al. (2017) Comparing efficacy and side effects of memantine vs. risperidone in the treatment of autistic disorder. Pharmacopsychiatry. 50(1), Read Abstract (New Window)
  
  
• Owley T. et al. (2006) A prospective, open-label trial of memantine in the treatment of cognitive, behavioral, and memory dysfunction in pervasive developmental disorders. Journal of Child and Adolescent Psychopharmacology. 16(5), Read Abstract (New Window)
  
  

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Updated

16 Jun 2018