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Yokukansan, also known as yi-gan san and TJ-54, is a traditional Asian herbal medicine.

Yokukansan is a kampo medicine containing JP Atractylodes lancea rhizome, JP poria sclerotium, JP Cndium rhizome, JP Uncaria hook, JP Japanese angelia root, JP Bupleurum root, and JP Glycyrrhiza (JP: Japanese Pharmcopoeia).

It has been used for the treatment of insomnia, irritability and convulsion for many years, and the pharmacological effects of TJ-54 is thought to be associated with 5-HT receptors.

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