According to Rimland (1990), in 1965 Russian scientists discovered that calcium pangamate led to considerable improvement in the speech of some children with learning disabilities who had not been able to use speech to communicate. Subsequent research has shown the essential factor in calcium pangamate to be dimethylglycine.
Soon afterward psychiatrist Allan Cott began to use pangamic acid on children, some of whom were autistic. Many of Cott's patients responded in the same way the Russian children had.
Following various legal battles, the sale of DMG is now permitted, as long as it is not referred to as a vitamin, and as long as it is sold as a food and not a drug.