Vitamin B6, Magnesium and Autism Ranking: Insufficient/Mixed evidence


According to Nye et al (2005),

“The use of mega-vitamin intervention began in the early 1950s with the treatment of schizophrenic patients. Pyridoxine (vitamin B6) was first reported to improve speech and language in some children diagnosed with "autism syndrome" when Bönisch observed that some participants showed improvement in speech and language. Other researchers also reported improved behavioural or biochemical functioning with schizophrenic participants given large doses of vitamin B6. These studies, along with individual anecdotal observations of parents and professionals, led Rimland and colleagues to assess the effectiveness of this orthomolecular treatment. Rimland had recognised that large doses of vitamin B6 produced several undesirable side effects (including irritability, hypersensitivity to sound and enuresis [involuntary urination], which could be countered with doses of magnesium [Mg]). Over the next 19 years, a number of investigators published studies in which attempts had been made to assess the effects of vitamin B6-Mg on a variety of characteristics such as verbal communication, non-verbal communication, interpersonal skills, and physiological function, in individuals with autism.”


21 Dec 2018
Last Review
01 Dec 2018
Next Review
01 Dec 2021