Anxiety drug reverses problems in mice with autism mutation
A widely used anxiety drug can eliminate some of the cognitive and social problems seen in mice missing a copy of ARID1B, a gene associated with autism.
The drug, clonazepam, boosts inhibitory brain activity. In addition to behavioral problems, the mutant mice have fewer neurons that suppress brain activity than controls do. So drugs such as clonazepam that ramp up inhibition may improve their function.
The results also hint at a treatment for people with mutations in ARID1B.
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- 4th January 2018