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Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits.

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Authors
V.T. Ramaekers, N. Blau, J.M. Sequeira, M.C. Nassogne, E.V. Quadros
Title
Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits.
Journal
Neuropediatrics
Year
2007
Volume
38
Issue
6
Page(s)
pp 276-281
Abstract Link
Read Abstract (New Window)
Publication Format
Journal Article
Efficacy Study/Review
Yes
Scientific Validity
Peer-Reviewed
Comments
This was primarily a study of serum folate, cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), and serum FR autoantibodies of the blocking type to determine the significance of folate receptor (FR) autoantibodies with respect to folate transport across the blood-CSF barrier in patients with early-onset low-functioning autism. However it also reported on clinical improvements, which were positive.
Keywords
Autism, Biomedical, Dietary Supplements, Folinic Acid, Intervention, Low Functioning / Severe, Oral / By Mouth, Rett Syndrome, Vitamin B-9, Vitamins

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